研究業績

論文

  1. Ichimura A, Miyazaki Y, Nagatomo H, Kawabe T, Nakajima N, Kim GE, Tomizawa M, Okamoto N, Komazaki S, Kakizawa S, Nishi M, Takeshima H. Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice. Cell Death Dis. 2023 Dec 20;14(12):848. doi: 10.1038/s41419-023-06285-y. PMID: 38123563; PMCID: PMC10733378.
  2. Yasuda T, Harada N, Hatoko T, Ichimura A, Ikeguchi-Ogura E, Murata Y, Wada N, Kiyobayashi S, Yamane S, Hirasawa A, Inagaki N. Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding. Am J Physiol Endocrinol Metab. 2023 May 1;324(5):E449-E460. doi: 10.1152/ajpendo.00329.2022. Epub 2023 Apr 19. PMID: 37074989.
  3. Ma J, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Kanou K, Kishikawa A, Ichimura A, Mizoguchi I. Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR120. Front Immunol. 2023 Jan 18;13:929690. doi: 10.3389/fimmu.2022.929690. PMID: 36741381; PMCID: PMC9889988.
  4. Miyazaki Y, Ichimura A, Kitayama R, Okamoto N, Yasue T, Liu F, Kawabe T, Nagatomo H, Ueda Y, Yamauchi I, Hakata T, Nakao K, Kakizawa S, Nishi M, Mori Y, Akiyama H, Nakao K, Takeshima H. C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth. Elife. 2022 Mar 15;11:e71931. doi: 10.7554/eLife.71931. PMID: 35287796; PMCID: PMC8923661.
  5. Ichimura A. Elucidation of the Physiological Functions of Membrane Proteins as Novel Drug Target Candidate Molecules. Biol Pharm Bull. 2021;44(9):1167-1173. doi: 10.1248/bpb.b21-00296. PMID: 34471043.
  6. Liu F, Xu L, Nishi M, Ichimura A, Takeshima H. Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages. Cell Calcium. 2021 Jun;96:102381. doi: 10.1016/j.ceca.2021.102381. Epub 2021 Feb 21. PMID: 33647639.
  7. Takeuchi H, Inuki S, Nakagawa K, Kawabe T, Ichimura A, Oishi S, Ohno H. Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso-Cyclization. Angew Chem Int Ed Engl. 2020 Nov 16;59(47):21210-21215. doi: 10.1002/anie.202009399. Epub 2020 Sep 11. PMID: 32770565.
  8. Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I. Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. Nat Commun. 2019 Sep 5;10(1):4007. doi: 10.1038/s41467-019-11978-0. PMID: 31488836; PMCID: PMC6728375.
  9. Kimura I, Ichimura A, Ohue-Kitano R, Igarashi M. Free Fatty Acid Receptors in Health and Disease. Physiol Rev. 2020 Jan 1;100(1):171-210. doi: 10.1152/physrev.00041.2018. Epub 2019 Sep 5. PMID: 31487233.
  10. Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation.
    Kishikawa A, Kitaura H, Kimura K, Ogawa S, Qi J, Shen WR, Ohori F, Noguchi T, Marahleh A, Nara Y, Ichimura A, Mizoguchi I.
    Front Endocrinol (Lausanne). 2019 Mar 15;10:157. doi: 10.3389/fendo.2019.00157. eCollection 2019.
    PMID: 30949128
  11. TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.
    Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H.
    Sci Signal. 2019 Apr 9;12(576). pii: eaaw4847. doi: 10.1126/scisignal.aaw4847.
    PMID: 30967513
  12. Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1. Kawaguchi SI, Gonda Y, Yamamoto T, Sato Y, Shinohara H, Kobiki Y, Ichimura A, Dan T, Sonoda M, Miyata T, Ogawa A, Tsujita T. Molecules. 2018 Apr 11;23(4). pii: E885. doi: 10.3390/molecules23040885.
  13. Complex formation between the vasopressin 1b receptor, β-arrestin 2 and the μ-opioid receptor underlies morphine tolerance. Koshimizu T, Honda K, Nagaoka-Uozumi S, Ichimura A, Kimura I, Nakaya M, Sakai S, Shibata K, Ushijima K, Fujimura A, Hirasawa A, Kurose H, Tsujimoto G, Tanoue A, Takano Y, Nature Neuroscience, 2018 Jun;21(6):820-833. doi: 10.1038/s41593-018-0144-y. Epub 2018 Apr 30.
  14. The natural flavonoid myricetin inhibits gastric H+, K+-ATPase., Miyazaki Y†, Ichimura A†, Sato S, Fujii T, Oishi S, Sakai H, Takeshima H. †, contributed equally, The European Journal of Pharmacology. 2018 Feb 5;820:217-221.
  15. Gm7325 is MyoD-dependently expressed in activated muscle satellite cells. Takei, D., Nishi, M., Fukada, S., Doi, M., Okamura, H., Uezumi, A., Zhang, L., Yoshida, M., Miyazato, M., Ichimura, A., Takeshima, H. Biomedical Research, 2017;38(3):215-219. doi: 10.2220/biomedres.38.215.
  16. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice. Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B. FASEB J. 2017 Jun;31(6):2625-2637.
  17. Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H. Biomed Res. 2017;38(3):215-219.
  18. TRIC-B Mutations Causing Osteogenesis Imperfecta, Biological Pharmaceutical Bulletin Vol. 39 (2016) No. 11 p. 1743-1747, Atsuhiko Ichimura, Hiroshi Takeshima1 *表紙に選出されました
  19. TRIC-B遺伝子変異による骨形成不全症 Osteogenesis imperfect caused by TRIC-B mutations, 医学のあゆみ, in press, 市村敦彦, 趙成珠, 竹島浩
  20. Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization. Zhao C, Ichimura A, Qian N, Iida T, Yamazaki D, Noma N, Asagiri M, Yamamoto K, Komazaki S, Sato C, Aoyama F, Sawaguchi A, Kakizawa S, Nishi M, Takeshima H. Sci Signal. 2016 May 17;9 (428):ra49. doi: 10.1126/scisignal.aad9055. PMID: 27188440,*表紙に選出されました。
  21. Nutritional Signaling via Free Fatty Acid Receptors. Int J Mol Sci. 2016 Mar 25;17(4):450. Miyamoto J, Hasegawa S, Kasubuchi M, Ichimura A, Nakajima A, Kimura I.
  22. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. Placencio VR, Ichimura A, Miyata T, DeClerck YA. 2015 Jul 24;10(7):e0133786.
  23. Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis. Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele de Strihou C, Miyata T. PLoS One. 10(4):e0124510. 2015 April
  24. Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation. Kasubuchi M, Hasegawa S, Hiramatsu T, Ichimura A, Kimura I. Nutrients. 14;7(4):2839-2849. 2015 Apr
  25. Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation. Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H. FEBS Lett. 28;589(10):1095-104. 2015 Apr
  26. A novel antidiabetic therapy: free Fatty Acid receptors as potential drug target. Sekiguchi H, Kasubuchi M, Hasegawa S, Pelisch N, Kimura I, Ichimura A*. Curr Diabetes Rev. 11(2):107-15. 2015
  27. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N. Cancer Biol Ther. 16(2):253-60. 2015
  28. Free fatty acid receptors as therapeutic targets for the treatment of diabetes. Ichimura A, Hasegawa S, Kasubuchi M, Kimura I. Front Pharmacol. 6;5:236. 2014 Nov
  29. Regulation of Energy Homeostasis via GPR120. Ichimura A*, Hara T, Hirasawa A. Front Endocrinol (Lausanne). 2014 Jul 11;5:111. doi: 10.3389/fendo.2014.00111. eCollection 2014
  30. Role of free fatty acid receptors in the regulation of energy metabolism. Hara T, Kashihara D, Ichimura A, Kimura I, Tsujimoto G, Hirasawa A. Biochim Biophys Acta. 2014 Sep;1841(9):1292-300. doi: 10.1016/j.bbalip.2014.06.002. Epub 2014 Jun 10.
  31. Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors. Hara T, Ichimura A, Hirasawa A. Front Endocrinol (Lausanne). 2014 Jun 2;5:83. doi: 10.3389/fendo.2014.00083. eCollection 2014.
  32. Plasminogen activator inhibitor-1 (PAI-1) molecule: new physiological roles and clinical applications. Dan T, Ichimura A, Pelisch N, Miyata K, Akahori K, Miyata T. Rinsho Ketsueki. 2014 Apr;55(4):396-404.
  33. Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Boe AE, Eren M, Murphy SB, Kamide CE, Ichimura A, Terry D, McAnally D, Smith LH, Miyata T, Vaughan DE Circulation. 2013 Nov 19;128:2318-24.
  34. Diet-induced obesity and GPR120. Ichimura A. Nihon Rinsho. 2013 Feb;71:350-4.
  35. Free fatty acid receptors and their role in regulation of energy metabolism. Hara T, Kimura I, Inoue D, Ichimura A, Hirasawa A. Rev Physiol Biochem Pharmacol. 2013;164:77-116.
  36. A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration. Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou C, Miyata T. Arterioscler Thromb Vasc Biol. 2013 May;33:935-42.
  37. Physiological functions of fatty acid receptors and their therapeutic potential. Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G. Nihon Yakurigaku Zasshi. 2012 Dec;140:275-9.
  38. 血管老化の関与 –AGE を中心に- 段孝、市村敦彦、松本幸子、宮田敏男.月刊循環器Circulation 2012 May; 2:51-8.
  39. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Nature. 2012 Feb 19;483:350-4.
  40. Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A. Am J Hypertens. 2012 May;25:604-11.
  41. 創薬標的としての遊離脂肪酸受容体：循環器疾患とメタボリックシンドローム.市村敦彦、原貴史、木村郁夫、平澤明、辻本豪三 血管 2011; 34: 145-152.
  42. Free fatty acid receptors and their physiological role in metabolic regulation. Hirasawa A, Hara T, Ichimura A, Tsujimoto G. Yakugaku Zasshi. 2011;131:1683-9.
  43. Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders. Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G. J Pharm Sci. 2011 Sep;100:3594-601.
  44. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G. Proc Natl Acad Sci U S A. 2011 May 10;108:8030-5.
  45. miRNAs and regulation of cell signaling. Ichimura A, Ruike Y, Terasawa K, Tsujimoto G. FEBS J. 2011 May;278(10):1610-8.
  46. MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells. Ichimura A, Ruike Y, Terasawa K, Shimizu K, Tsujimoto G. Mol Pharmacol. 2010 Jun;77:1016-24.
  47. 脂肪酸受容体：メタボリックシンドロームと循環器系疾患 木村郁夫、井上大輔、前田岳志、宮内諭、市村敦彦、平澤明、辻本豪三 血管 2010; 33: 81-87.
  48. New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract. Miyauchi S, Hirasawa A, Ichimura A, Hara T, Tsujimoto G. J Pharmacol Sci. 2010;112(1):19-24.
  49. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Ichimura A, Hirasawa A, Hara T, Tsujimoto G. Prostaglandins Other Lipid Mediat. 89(3-4):82-8. 2009 Sep
  50. Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells. Terasawa K, Ichimura A, Sato F, Shimizu K, Tsujimoto G. FEBS J. 2009 Jun;276(12):3269-76.
  51. Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines. Ruike Y, Ichimura A, Tsuchiya S, Shimizu K, Kunimoto R, Okuno Y, Tsujimoto G. J Hum Genet. 2008;53(6):515-23.
  52. In silico approach to identify the expression of the undiscovered molecules from microarray public database: identification of odorant receptors expressed in non-olfactory tissues. Ichimura A, Kadowaki T, Narukawa K, Togiya K, Hirasawa A, Tsujimoto G. Naunyn Schmiedebergs Arch Pharmacol. 2008 Apr;377(2):159-65.

著書

  1. Chapter Title: Polymorphic Variation in FFA Receptors: Functions and Consequences
    Atsuhiko Ichimura*
    Fre Fatty Acid Receptors book series Handbook of Experimental Pharmacology (http://www.springer.com/series/164) , 2017;236:133-158.